Anti-ERBB2 Antibody, Rabbit Polyclonal
產品編號：PA00188HuA10
$ 詢價
規(guī)格 50uL 100uL 200uL 可選
產品名稱：Anti-ERBB2 Antibody, Rabbit Polyclonal
經驗證的應用： WB
交叉反應：/
特異性：human ERBB2
免疫原：Recombinant human ERBB2 protein, fragment Tyr343~Thr652; UniprotKB: P04626
制備方法：Produced in rabbits immunized with human ERBB2, and purified by antigen affinity chromatography.
來源：Polyclonal Rabbit IgG
純化：Immunogen affinity purified
緩沖液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
偶聯物：Unconjugated
狀態(tài)：Liquid
運輸方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
儲存條件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
別稱：CD340, EGFR2, HER-2/neu, HER2, NEU, MLN 19, NGL, TKR1, p185, Epidermal Growth Factor Receptor 2, V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog
背景信息：HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase- mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas. This antibody raised against a synthesized peptide corresponding to 1237-1255aa of human HER2 recognizes the 185-kDa full-length glycosylated form and other lower molecular-mass forms of HER2, including the truncated form.
全稱：Receptor tyrosine-protein kinase erbB-2 (ERBB2)
說明書：待上傳